منابع مشابه
Action of interferon in enucleated cells.
Interferon induces protection of enucleated BSC-1 cells against infectious vesicular stomatitis virus production if cells are treated before, but not after, enucleation.
متن کاملGrowth of Chlamydia trachomatis in enucleated cells.
Chlamydia trachomatis is an obligate intracellular parasite of eucaryotic cells. Little is known about the role of the host in supporting chlamydial replication beyond the facts that host cells provide ATP and that de novo host protein synthesis is not required for bacterial growth. To further explore potential contributions of host nuclear function to chlamydial development, we questioned whet...
متن کاملRegulation of cholesterol biosynthesis in enucleated cells.
In cells that had been physically enucleated after treatment with cytochalasin B (cytoplasts) levels of cholesterol synthesis and 3-hydroxy-3-methylglutaryl coenzyme A reductase activity were nearly constant over a 6-h period of time. The ratio of the inactive to the active form of the reductase was unaltered by enucleation and did not change when the cytoplasts were incubated at 37%. The addit...
متن کاملMechanism of Interferon Action
The double-stranded RNA (dsRNA)-dependent protein kinase which catalyzes the phosphorylation of ribosome-associated protein Pl and the a subunit of eukaryotic protein synthesis initiation factor 2 (eIF-2) was purified and characterized from mouse fibroblast L929 cells treated with either natural or recombinant interferon and from untreated cells. The dsRNA-dependent Pl/eIF-2a kinase was purifie...
متن کاملInterferon action II. Membrane-bound alkaline ribonuclease activity in chick embryo cells manifesting interferon-mediated interference.
Membrane fractions from chick embryo cells manifesting viral interference mediated by interferon or poly(I)-poly(C) contain high levels of an alkaline ribonuclease. Enhanced RNase activity is not observed when inhibitors of cell protein or RNA synthesis are present during interferon treatment, or when heterologous interferon is used. The RNase associated with comparable membrane fractions from ...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 1975
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.15.2.428-429.1975