Actinomycin D Binds Strongly to d(CGACGACG) and d(CGTCGTCG)
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چکیده
منابع مشابه
Experimental studies with actinomycin D.
Actinomycin D has been tested on mouse tu mors, with varying degrees of success, as an anti-neoplastic agent. Dramatic inhibition of some ascites (mouse) tumors has been reported by Sugiura (14) and Gregory et al. (6). Reilly (11) and Sugiura (14) are in agreement that actino-mycin D has slight antineoplastic activity against S-180, and Farber (3) demonstrated antitumor activity against the mal...
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For the purpose of revealing whether the sensitivity of the erythropoiesis to actinomycin D (AMD) differs among different animal species, and to see the acting site of AMD on erythroid cell specialization stage, the author observed the hourly change of the blood cell counts and bone marrow cells after AMD administration to mice, rats and rabbits, and obtained the following results: 1. The data ...
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At high cytotoxic concentrations, actinomycin D (ActD) blocks transcription, decreasing levels of MDM2 and thus causing p53 stabilization. At low cytostatic concentrations, ActD causes ribosomal stress, which decreases MDM2 activity, resulting in p53 stabilization and activation. ActD can thus be used for p53-based cyclotherapy. We analyzed pathways mediating ActD-induced p53 expression. Inhibi...
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We have used equilibrium dialysis and other techniques to examine the actinomycin D binding sites on unsubstituted and halodeoxyuridine-substituted DNAs. Some of the actinomycin D binding sites present on halodeoxyuridine-substituted DNAs have an enhanced affinity for actinomycin D compared to the standard binding sites present on unsubstituted DNA. Kinetic studies indicate that actinomycin D d...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2000
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(00)76457-5