Acquired von Willebrand Syndrome

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Acquired von Willebrand syndrome in aortic stenosis.

BACKGROUND Aortic-valve stenosis can be complicated by bleeding that is associated with acquired type 2A von Willebrand syndrome. However, the prevalence and cause of the hemostatic abnormality in aortic stenosis are unknown. METHODS We enrolled 50 consecutive patients with aortic stenosis, who completed a standardized screening questionnaire to detect a history of bleeding. Forty-two patient...

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Acquired von Willebrand syndrome in myeloproliferative disorder

We present a woman (age: 57 years) with an excessive bleeding episode under acetylsalicylic acid after bone marrow puncture due to an acquired von Willebrand syndrome (avWS) in the context of a myeloproliferative disorder. The laboratory features showed a high platelet concentration and a qualitative defect of von Willebrand factor (vWF) with a low normal vWF ristocetin cofactor activity, a nor...

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Acquired von Willebrand syndrome in children with patent ductus arteriosus.

Since acquired von Willebrand syndrome (AVWS) was first described in 1968, approximately 270 cases have been reported in the literature. In 12% of these cases AVWS was secondary to cardiovascular disorders. Only two of these reports dealt with children. 3 Gill and colleagues reported on 12 patients with non-cyanotic heart defects (atrial and ventricular septal defects, aortic stenosis) and abno...

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How I treat the acquired von Willebrand syndrome.

The acquired von Willebrand syndrome (AVWS) is a bleeding disorder that is frequently unrecognized or is misdiagnosed as von Willebrand disease. AVWS is characterized by structural or functional defects of von Willebrand factor (VWF) that are secondary to autoimmune, lymphoproliferative or myeloproliferative, malignant, cardiovascular, or other disorders. VWF abnormalities in these disorders ca...

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Acquired von Willebrand syndrome in children with aorticand pulmonary stenosis

INTRODUCTION This prospective study was planned to investigate the frequency and relationship of acquired von Willebrand syndrome (AVWS) with aortic and pulmonary stenosis in patients. METHODS A total of 84 children, ranging from two to 18 years of age, were enrolled in this study. Of these, 28 had isolated aortic stenosis, 32 had isolated pulmonary stenosis and 24 were healthy. Children with...

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ژورنال

عنوان ژورنال: Advances in Clinical and Experimental Medicine

سال: 2016

ISSN: 1899-5276

DOI: 10.17219/acem/64942