Acquired coagulation factor deficiencies in leukemia

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Multiple congenital coagulation deficiencies.

A 6-week-old infant is presented who suffered from a congenital haemorrhagic disorder which caused death from subdural haemorrhage following mild trauma. Haematological investigation revealed deficiencies of factor VII and Christmas factor. Prower-Stuart factor was probably also deficient although investigation of this clotting factor was carried out only on serum obtained at necropsy.

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Acquired deficiency of coagulation factor VII

Factor VII (FVII) is found in small amounts in plasma and has a very short half-life in circulation. FVII is vitamin K-dependently synthesized in the liver. As such, hepatopathies, vitamin K deficiency, or use of vitamin K antagonists is the cause of acquired deficiency. Other types of acquired FVII deficiencies are rare.1 Here we describe a case of acquired factor VII deficiency associated to ...

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Acquired Coagulation Inhibitor Delaying

A 14-yr-old girl with Down syndrome develimmune sera revealed that the inhibitor was oped a unique type of circulating inhibitor an immunoglobulin of lgG class with both causing a mild bleeding tendency and interand A determinants. Isolated inhibitor defering strongly with coagulation tests, includlayed the release of fibrinopeptide A from a ing reptilase time, and with the reaction of normal f...

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Large deletions play a minor but essential role in congenital coagulation factor VII and X deficiencies.

UNLABELLED Congenital factor VII (FVII) and factor X (FX) deficiencies belong to the group of rare bleeding disorders which may occur in separate or combined forms since both the F7 and F10 genes are located in close proximity on the distal long arm of chromosome 13 (13q34). We here present data of 192 consecutive index cases with FVII and/or FX deficiency. 10 novel and 53 recurrent sequence al...

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Perioperatively acquired disorders of coagulation

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ژورنال

عنوان ژورنال: Cancer

سال: 1970

ISSN: 0008-543X,1097-0142

DOI: 10.1002/1097-0142(197011)26:5<1097::aid-cncr2820260518>3.0.co;2-2