Acidotoxicity Trumps Excitotoxicity in Ischemic Brain
نویسندگان
چکیده
منابع مشابه
Acidotoxicity trumps excitotoxicity in ischemic brain.
This question remains incompletely answered 2 decades later, during which excitatory amino acids and calcium toxicity have been central research and therapeutic targets. Recently, attention has returned to a central neurochemical feature of ischemic brain injury, acidosis, which was focused on in Plum’s lecture. Targeting this effector of injury as therapy for brain ischemia now may be closer a...
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Intracellular calcium toxicity remains the central feature in the pathophysiology of ischaemic cell death in brain. Glutamate-gated channels have been thought to be the major sites of ischaemia-induced toxic calcium entry, but the failure of glutamate antagonists in clinical trials has suggested that glutamate-independent mechanisms of calcium entry during ischaemia must exist and may prove cen...
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Cell adhesion molecules (CAMs) are involved in synaptic plasticity and neuronal survival in the adult brain. Neuroplastin 65 (Np65), one member of the immunoglobulin superfamily of CAMs, is brain-specific and highly expressed in rodent forebrain. The roles of Np65 in synaptic plasticity have been confirmed, however, whether Np65 affects neuronal survival remains unknown. To address this gap, we...
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ژورنال
عنوان ژورنال: Archives of Neurology
سال: 2006
ISSN: 0003-9942
DOI: 10.1001/archneur.63.10.1368