Acid-base properties of substituted 6-nitro-N-(R-phenyl)anthranilic acids
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Anti-inflammatory properties of N-phenylanthranilic acid derivatives in relation to uncoupling of oxidative phosphorylation.
It has been known that a variety of non-steroidal anti-inflammatory drugs uncouple oxidative phosphorylation in mitochondria (1-5). Adams and Cobb (2) have studied whether or not the inhibition of inflammation by non-steroidal drugs was related to their in vitro capacity to uncouple oxidative phosphorylation. Whitehouse (6) has made an extensive survey on this problem. We have reported that...
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In the title compound, C(18)H(17)N(5)O(2), the pyrimidine ring makes dihedral angles of 66.09 (12), 71.39 (13) and 56.7 (3)° with two phenyl rings and the nitro group, respectively. The dihedral angle between the two phenyl rings is 44.05 (14)°.
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In the title compound, C(11)H(9)ClN(4)O(2), the dihedral angle between the aromatic rings is 79.67 (8)°. π-π stacking between centrosymmetrically related pairs of pyrimidine rings occurs along [100] [centroid-centroid separations = 3.4572 (8) and 3.5433 (7) Å].
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ژورنال
عنوان ژورنال: Scripta Scientifica Pharmaceutica
سال: 2015
ISSN: 2367-5500,2367-6000
DOI: 10.14748/ssp.v1i1.1009