Achieving neuroprotection with LRRK2 kinase inhibitors in Parkinson disease
نویسندگان
چکیده
منابع مشابه
Achieving neuroprotection with LRRK2 kinase inhibitors in Parkinson disease
In the translation of discoveries from the laboratory to the clinic, the track record in developing disease-modifying therapies in neurodegenerative disease is poor. A carefully designed development pipeline built from discoveries in both pre-clinical models and patient populations is necessary to optimize the chances for success. Genetic variation in the leucine-rich repeat kinase two gene (LR...
متن کاملLRRK2 and Parkinson disease.
OBJECTIVES To review the molecular genetics and functional biology of leucine-rich repeat kinase 2 (LRRK2) in parkinsonism and to summarize the opportunities and challenges to develop interventions for Parkinson disease (PD) based on this genetic insight. DATA SOURCES Publications cited are focused on LRRK2 biology between 2004 and March 2009. STUDY SELECTION Literature selected was based o...
متن کاملP 105: The Role of LRRK2 Inhibitors in Treatment of Parkinson’s Disease
Parkinson’s disease is the second most common age associated neuron degenerative disorder in developed societies. With the prevalence ranging from 41 per 100000 in the fourth decade of life to over 1900 per 100000 in people over 80 years of age.it characterized clinically by resting tremor, slowness of movement, rigidity and postural instability in the result of progressive loss of dopami...
متن کاملInhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models.
Mutations in leucine-rich repeat kinase 2 (LRRK2) have been identified as a genetic cause of familial Parkinson's disease (PD) and have also been found in the more common sporadic form of PD, thus positioning LRRK2 as important in the pathogenesis of PD. Biochemical studies of the disease-causing mutants of LRRK2 implicates an enhancement of kinase activity as the basis of neuronal toxicity and...
متن کاملInhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in C. elegans and Drosophila Parkinson’s disease models
Mutations in LRRK2 have been identified as a genetic cause of familial Parkinson’s disease (PD), and mutations in LRRK2 have also been found in the more common sporadic form of PD, thus positioning LRRK2 as important in the pathogenesis of PD. Biochemical studies of the disease causing mutants of LRRK2 implicates an enhancement of kinase activity as the basis of neuronal toxicity and thus possi...
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ژورنال
عنوان ژورنال: Experimental Neurology
سال: 2017
ISSN: 0014-4886
DOI: 10.1016/j.expneurol.2017.07.019