Acetylcholinesterase Enzyme Inhibitor and Antioxidant Activities from A Mixture Extracts of Black Tea, Red Betel, Cinnamon and Curcuma

Alzheimer's Disease (AD) is one of the consequences impaired functioning acetylcholine which can be hydrolyzed by enzyme acetylcholinesterase. treatment carried out using two approaches, namely compounds (acetylcholinesterase inhibitors) and noncholinergics (antioxidants). There are commercial drugs that slow progression Alzheimer's, but their use cause excessive side effects. The herbal plants as a cure for disease has been proven to safer does not Herbal used developed black tea, red betel, curcuma, cinnamon. This study determined extracts betel leaf, cinnamon's formula have best antioxidant activity level inhibition acetylcholinesterase enzyme. F1 (cinnamon), F5 (cinnamon, curcuma), F6 (cinnamon tea), F11 curcuma) were formulations in each type sample based on inhibitory AChE enzymes antioxidants activity. (cinnamon) most effective extract all analyzed this study.
 
 Keywords: Acetylcholinesterase; Alzheimer; Black Tea; Cinnamon; Red Betel; Curcuma