Acetylation regulates ribonucleotide reductase activity and cancer cell growth
نویسندگان
چکیده
منابع مشابه
A small-molecule blocking ribonucleotide reductase holoenzyme formation inhibits cancer cell growth and overcomes drug resistance.
Ribonucleotide reductase (RNR) is an attractive target for anticancer agents given its central function in DNA synthesis, growth, metastasis, and drug resistance of cancer cells. The current clinically established RNR inhibitors have the shortcomings of short half-life, drug resistance, and iron chelation. Here, we report the development of a novel class of effective RNR inhibitors addressing t...
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The relationship between ribonucleotide reductase and tumor growth rate was measured in a series of rat hepatomas of different growth rates. An excellent correlation was found between tumor growth rate and the specific activity of ribonucleotide reductase. Differences of ZOO-fold in enzyme specific activities exist between the very fast and the slow growing hepatomas. This represents the larges...
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possible cancer chemotherapeutic agents. Howeven, pre himinary data indicate that these compounds are toxic and are not effective in humans (4, 14). In order to develop an effective chemothemapeutic agent for which the mode of action is inhibition of nibonucleotide meductase activity, a number of ahiphatic and aromatic hydroxamic acids and their corresponding amides and esters were synthesized ...
متن کاملInhibition of ribonucleotide reductase activity by IC202C.
suppresses DNAsynthesis by inhibition of ribonucleotide reductase.4) Ribonucleotide reductase plays an essential role in DNAsynthesis in most organisms.5) The enzyme is a nonheme iron-containing protein, which requires ATPand Mg2+ as co factors. As previously reported that IC202C has art affinity against Fe(III) ion,3) we have examined the effect of IC202C on ribonucleotide reductase activity u...
متن کاملAtaxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis.
Ataxia-telangiectasia mutated (ATM) kinase orchestrates nuclear DNA damage responses but is proposed to be involved in other important and clinically relevant functions. Here, we provide evidence for what we believe are 2 novel and intertwined roles for ATM: the regulation of ribonucleotide reductase (RR), the rate-limiting enzyme in the de novo synthesis of deoxyribonucleoside triphosphates, a...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2019
ISSN: 2041-1723
DOI: 10.1038/s41467-019-11214-9