Acetaminophen induced Stevens Johnson syndrome - Toxic Epidermal Necrolysis Overlap Syndrome: A rare Adverse Reaction
نویسندگان
چکیده
Stevens Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are hyper sensitive life - threatening rare dermatological reactions. In SJS TEN overlap syndrome, the extent severity of epidermal detachment is 10- 30%. Drugs like sulfonamides, nonsteroidal anti- inflammatory agents, antibiotics anticonvulsants commonest precipitants. Here, we present a case in previously normal 11 years old girl after acetaminophen intake for fever. This report intended to make paediatricians aware that adverse reaction can develop with drug which supposed be safest antipyretic paediatrics.
منابع مشابه
Acetaminophen induced Steven Johnson syndrome-toxic epidermal necrolysis overlap.
Steven Johnson Syndrome and Toxic Epidermal Necrolysis are rare but severe form of hypersensitivity inflammatory reactions to multiple offending agents including drugs. Acetaminophen is extensively used due to its analgesic and anti-pyretic properties. It is rendered to be relatively safe, with hepatotoxicity considered to be the major adverse effect. However, very few cases of Steven Johnson S...
متن کامل[Stevens-Johnson syndrome/toxic epidermal necrolysis].
Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a severe skin reaction most often triggered by particular medications. Although Stevens-Johnson syndrome and toxic epidermal necrolysis were once thought to be separate conditions, they are now considered part of a continuum. Stevens-Johnson syndrome represents the less severe end of the disease spectrum, and toxic epidermal necro...
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Three cases are described in which Stevens-Johnson syndrome progressed in the course of a few days to toxic epidermal necrolysis. Trimethoprim-sulfamethoxazole, allopurinol in combination with hydrochlorothiazide, phenytoin and possibly ampicillin were implicated in the causation of the disease.
متن کاملToxic Epidermal Necrolysis and Stevens-Johnson Syndrome
The term toxic epidermal necrolysis (TEN) was introduced in 1956 by Lyell to describe four patients with a syndrome featured by extensive epidermal detachment with mucous membrane involvement, leaving the skin surface looking scalded. Necrolysis denotes necrosis and full thickness detachment of the epidermis. Toxic means severe constitutional symptoms and complications. Stevens-Johnson syndrome...
متن کاملLevofloxacin induced Stevens-Johnson syndrome/ toxic epidermal necrolysis overlap syndrome: case reports
Fluoroquinolones are widely used because of their broad spectrum of activity. Their benefit-risk profile needs careful evaluation as they can induce T cell-dependent reactions including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Here we present two rare cases of SJS/TEN overlap syndrome and SJS caused by levofloxacin. Case 1. A 70-year-old woman with a history of chron...
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ژورنال
عنوان ژورنال: Journal of Nepal Paediatric Society
سال: 2022
ISSN: ['1990-7982', '1990-7974']
DOI: https://doi.org/10.3126/jnps.v42i1.39225