Accumulation Pharmacokinetics of Tobramycin
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چکیده
منابع مشابه
Tobramycin population pharmacokinetics in neonates
Objective: To establish a tobramycin dosing schedule for neonates of various gestational ages. Methods: This was a retrospective study with prospective validation. A retrospective study in 470 neonates, with suspected septicemia in the first week of life, was performed. All patients received tobramycin according to the following scheme: neonates with a gestational age of less than 28 weeks rece...
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The two-compartment tissue accumulation pharmacokinetics of tobramycin and netilmicin were compared in 11 normal volunteers by using a crossover design. After each 1.0-mg/kg (body weight) dose, serum was collected for 96 h, and complete 24-h urine collections were obtained for a total of 30 days. Two months of washout were required before crossover. Concentrations in serum and urine were measur...
متن کاملThe pharmacokinetics of Simplex-tobramycin bone cement.
We prospectively investigated a consecutive series of ten patients undergoing a cemented primary total hip replacement (THR) for osteoarthritis in order to establish the elution characteristics of Simplex-tobramycin bone cement (Howmedica, Limerick, Ireland). Specimens of blood, urine and drainage fluid were collected for 72 hours postoperatively. Very high concentrations of tobramycin were fou...
متن کاملPopulation Pharmacokinetics of Inhaled Tobramycin Powder in Cystic Fibrosis Patients
Tobramycin powder for inhalation (TOBI Podhaler or TIP) is approved for the treatment of Pseudomonas aeruginosa airway infection in patients with cystic fibrosis (CF). A population pharmacokinetic model for tobramycin inhalation powder (TIP) in CF patients was developed to characterize the effect of covariates including body mass index (BMI) and lung function (forced expiratory volume in 1 s as...
متن کاملPharmacokinetics of cefoperazone and tobramycin alone and in combination.
Certain beta-lactams have been shown to increase the clearance of tobramycin. We evaluated the pharmacokinetics of cefoperazone and tobramycin, alone and in combination, in healthy volunteers. No significant alteration in pharmacokinetic behavior was noted for cefoperazone or tobramycin alone or in combination.
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1978
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.13.4.649