Accumulation of type VI collagen in cardiomyopathic monkey hearts
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چکیده
منابع مشابه
Immunoglobulin binding in cardiomyopathic hearts.
Bound gamma globulin was demonstrated by the direct immunofluorescent technique in heart tissue from three patients with severe congestive cardiomyopathy. In two of these patients complement (,81C) was also bound to the heart muscle. Heart tissue from one of six patients who died of myocardial infarction showed a trace of bound gamma globulin, but no bound complement. During life, the heart in ...
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The collagen type VI-related disorders are nowadays considered to be a continuum of overlapping phenotypes with Bethlem myopathy at the mild end and Ullrich congenital muscular dystrophy (UCMD) at the severe end. In between these phenotypes there are collagen type VI-related limb-girdle muscular dystrophy and myosclerosis myopathy. Most cases of Bethlem myopathy have autosomal dominant inherita...
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Normal adult rabbit corneas were digested with 5% pepsin and their collagens extracted with acetic acid. Collagen extracts were fractionated by differential salt precipitation. The 2.5 M NaCl fraction was then redissolved with tris buffer and precipitated with sodium acetate. The precipitate contained a high-molecular-weight disulfide-bonded aggregate which, upon reduction with mercaptoethanol,...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2009
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.23.1_supplement.928.5