ACCORD: 5-year outcomes of intensive glycemic control
نویسندگان
چکیده
منابع مشابه
Intensive glycemic control in the ACCORD and ADVANCE trials.
Diabetes is associated with a reduced lifespan, largely as a consequence of cardiovascular disease.1-3 Although diabetes significantly increases the risk of cardiovascular events,1 the relative increase in events for each percent increase in glycated hemoglobin is modest.4 Microvascular complications of diabetes remain the leading causes of blindness and renal failure in the developed world and...
متن کاملNine-Year Effects of 3.7 Years of Intensive Glycemic Control on Cardiovascular Outcomes
OBJECTIVE In the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial, ∼4 years of intensive versus standard glycemic control in participants with type 2 diabetes and other cardiovascular risk factors had a neutral effect on the composite cardiovascular outcome, increased cardiovascular and total mortality, and reduced nonfatal myocardial infarction. Effects of the intervention duri...
متن کاملIntensive Glycemic Control Is Not Associated With Fractures or Falls in the ACCORD Randomized Trial
OBJECTIVE Older adults with type 2 diabetes are at high risk of fractures and falls, but the effect of glycemic control on these outcomes is unknown. To determine the effect of intensive versus standard glycemic control, we assessed fractures and falls as outcomes in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) randomized trial. RESEARCH DESIGN AND METHODS ACCORD participant...
متن کاملPoint: Intensive Glycemic Control and Mortality in ACCORD—A Chance Finding?
The Action to Control Cardiovascular Risk in Diabetes (ACCORD) study was designed to assess whether intensive glucose management aimed at a normal A1C ( 6%) versus standard therapy aimed at an A1C of 7–8% would reduce the risk of cardiovascular disease as reflected by the incidence of a major adverse cardiac event (MACE) such as cardiovascular death, nonfatal myocardial infarction, or nonfatal ...
متن کاملIntensive Glycemic Control and the Prevention of Cardiovascular Events: Implications of the ACCORD, ADVANCE, and VA Diabetes Trials
D iabetes is defined by its association with hyperglycemia-specific microvascular complications; however, it also imparts a twoto fourfold risk of cardiovascular disease (CVD). Although microvascular complications can lead to significant morbidity and premature mortality, by far the greatest cause of death in people with diabetes is CVD. Results from randomized controlled trials have demonstrat...
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ژورنال
عنوان ژورنال: Nature Reviews Endocrinology
سال: 2011
ISSN: 1759-5029,1759-5037
DOI: 10.1038/nrendo.2011.67