Acceptability of Long-Acting Injectable Cabotegravir (CAB LA) in HIV-Uninfected Individuals: HPTN 077
نویسندگان
چکیده
منابع مشابه
OPINION Cabotegravir long-acting for HIV-1 prevention
Purpose of review Preexposure prophylaxis (PrEP) with daily Truvada has demonstrated clinical efficacy against HIV-1 acquisition that correlates with high adherence. Long-acting antiretroviral drugs offer an alternative to daily regimens and may improve PrEP adherence. This review summarizes the preclinical nonhuman primate studies for evaluating the efficacy of cabotegravir long-acting as PrEP...
متن کاملFormulation and pharmacology of long-acting cabotegravir
PURPOSE OF REVIEW Long-acting cabotegravir may provide a novel therapeutic option for both the treatment and prevention of HIV-1 infection that does not necessitate adherence to a daily regimen. The present review will highlight the unique formulation properties and pharmacologic attributes of long-acting cabotegravir nanosuspension. RECENT FINDINGS Cabotegravir is a potent integrase strand t...
متن کاملLong-acting injectable antiretrovirals for HIV treatment and prevention
PURPOSE OF REVIEW Long-acting antiretroviral (ARV) drugs may improve adherence to therapy and extend opportunities for therapeutic or prophylactic intervention to underserved patient populations. This review focuses on recent advances in the development of small molecule long-acting injectable ARV agents. RECENT FINDINGS The need for combination ART and physicochemical and dosing limitations ...
متن کاملThe promise and pitfalls of long-acting injectable agents for HIV prevention.
PURPOSE OF REVIEW Preexposure prophylaxis for HIV prevention is highly effective when taken as prescribed. Adherence to required dosing regimens for protection may pose challenges. Long-acting agents for HIV prevention may have the potential to improve adherence via favorable pharmacokinetics supportive of infrequent dosing. This review focuses on the potential benefits and considerations for t...
متن کاملLong-acting injectable antipsychotics: recommendations for clinicians.
A major source of limitation to the real effectiveness of antipsychotics is the high rate of patient nonadherence or, more frequently, partial adherence. Using long-acting injectable (LAI) formulations is likely to reduce the impact of such adherence problems. Conversely, the use of LAIs in Canada remains low relative to many other jurisdictions. Based on effectiveness data from randomized cont...
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ژورنال
عنوان ژورنال: AIDS and Behavior
سال: 2020
ISSN: 1090-7165,1573-3254
DOI: 10.1007/s10461-020-02808-2