Accelerated Alpha Radiation Damage in a Ceramic Waste Form, Interim Results

Radiation Damage of a Glass-bonded Zeolite Waste Form Using Ion Irradiation

Glass-bonded zeolite is being considered as a candidate ceramic waste form for storing radioactive isotopes separated from spent nuclear fuel in the electrorefining process. To determine the stability of glass-bonded zeolite under irradiation, transmission electron microscope samples were irradiated using high energy helium, lead, and krypton. The major crystalline phase of the waste form, whic...

Interim analysis: the alpha spending function approach.

Interim analysis of accumulating data in a clinical trial is now an established practice for ethical and scientific reasons. Repeatedly testing interim data can inflate false positive error rates if not handled appropriately. Group sequential methods are a commonly used frequentist approach to control this error rate. Motivated by experience of clinical trials, the alpha spending function is on...

Radiation track and DNA damage

Advanced Radiation-Resistant Ceramic Composites

Ceramic matrix composites (CMC’s), particularly silicon carbide (SiC) fiber-reinforced SiC-matrix (SiC/SiC) composites, have been studied for advanced nuclear energy applications for more than a decade. The perceived potentials for advanced SiC/SiC composites include the ability to operate at temperature regimes much higher than heat-resistant alloys, the inherent low inducedactivation nuclear ...

Radiation-induced accelerated senescence

Damage to normal tissue is a limiting factor for clinical radiation for cancer eradication. Ionizing radiation can induce a variety of cellular responses, including apoptosis, necrosis, necroptosis, autophagy, and accelerated senescence. The molecular mechanisms of radiationinduced cellular injury depend on a number of factors, including radiation dosage and dose rate, cell type, transformed st...