Abstract No. 129 Histopathological Analysis after Transarterial Radioembolization with Yttrium-90 Resin Microspheres

To identify effects of transarterial radioembolization (TARE) with Yttrium-90 resin microspheres on histopathological analysis. All patients who underwent TARE to any liver tumor followed by a resection were included in this retrospective, IRB-approved study (n = 26). was performed using 3-day pre-calibration 90Y SPECT/CT or PET/CT. Pathologic analysis board certified pathologist 34 years experience. Degree response recorded as percentage nonviable tumor, (either due necrosis fibrosis) and number beads counted 5X zoom normal liver. Three separate regions the assessed, average being reported. Extensive defined ≥90% nonviable. Continuous variables are reported median interquartile range categorical numbers percentage. One patient without pathologic excluded (final cohort 25). Median age 68 (60-70, 64% male), 14 (56%) having intrahepatic cholangiocarcinoma, 10 (40%) hepatocellular carcinoma, 1 (4%) metastatic colorectal carcinoma. MIRD dosimetry target dose 150 (120-200) Gy used 19 (76%) patients, partition 200 one patient, BSA 5 (20%). A activity 1.7 (1.1-2.1) GBq delivered. Resection occurred 110 (74-162) days after TARE. revealed rate 90 (60-95) %, 100% 4 (16%), 90-99% 9 (36%), 50-89% (40%), < 50% 2 (8%) patients. Patients prescribed ≥180 had 67% extensive response, compared 38% 180 (P 0.18). On 5× zoom, tumoral region received 87 (53-115) 20 (10-30) 0.01). receiving >90 necrosis, those beads. Achieving stasis associated higher degree fibrosis (49%) antegrade flow (5%, P 0.01), whereas (45%) (30%, 0.04). yttrium-90 is majority while suggesting that leads particles thus leading response.