Abstinence from Cocaine Reduces High-Risk Responses on a Gambling Task

Comparison of p300 in risk-seeker and risk-averse people during simple gambling task

Risk preference, the degree of tendency to take risk, has a fundamental role at individual and social health and is divided to risk seeker and risk averse. Therefore, the study of neural corelates of risk preferences is essential at the field of psychology and psychiatry. The current study aimed to examine and compare an ERP component named P300 between subjects with different risk preferences....

PM286. Cocaine modifies preference of choice in rat gambling task

Background: Ketamine, an antagonist on N-methyl-D-aspartate (NMDA) receptor, can produce neurobehavioral changes ranging from mood alterations and psychotic episodes in human to hyperactivity and stereotyped motion in mice. In the study, we tested the pharmacological properties of ketamine on anxiety, locomotion and motor activity. Materials and Methods: Subjects were C57BL/6J mice with age of ...

Widespread disruption in brain activation patterns to a working memory task during cocaine abstinence.

Cocaine abstinence is associated with impaired performance in cognitive functions including attention, vigilance and executive function. Here we test the hypothesis that cognitive dysfunction during cocaine abstinence reflects in part impairment of cortical and subcortical regions modulated by dopamine. We used functional magnetic resonance imaging (fMRI) to study brain activation to a verbal w...

Adolescents’ heightened risk-seeking in a probabilistic gambling task

This study investigated adolescent males' decision-making under risk, and the emotional response to decision outcomes, using a probabilistic gambling task designed to evoke counterfactually mediated emotions (relief and regret). Participants were 20 adolescents (aged 9-11), 26 young adolescents (aged 12-15), 20 mid-adolescents (aged 15-18) and 17 adults (aged 25-35). All were male. The ability ...

Youth Gambling and Problem Gambling: Another High Risk Behavior