منابع مشابه
Absolute structure determination: pushing the limits.
It was the Softenon disaster (see Wikipedia) that made the pharmaceutical industry fully aware of the importance of knowing the enantiomeric purity and chirality of drugs and their metabolites. This disaster involved the chiral drug Thalidomide (Fig. 1) that was sold in the 1950s as a racemate under various brand names such as Contergan and Softenon. It was shown in the early 1960s that only th...
متن کاملDetermination of absolute structure using Bayesian statistics on Bijvoet differences
A new probabilistic approach is introduced for the determination of the absolute structure of a compound which is known to be enantiopure based on Bijvoet-pair intensity differences. The new method provides relative probabilities for different models of the chiral composition of the structure. The outcome of this type of analysis can also be cast in the form of a new value, along with associate...
متن کاملAbsolute structure and absolute configuration.
Fundamental notions concerning absolute structure and absolute configuration, and their determination from single-crystal diffraction measurements, are presented and reviewed. A glossary of terms with definitions useful in this field is provided. For absolute structure and its determination, the separate but interacting influences of the structure and the inversion-distinguishing power of an X-...
متن کاملAbsolute Neutrino Mass Determination
We discuss four approaches to the determination of absolute neutrino mass. These are the measurement of the zero-neutrino double beta decay rate, of the tritium decay end-point spectrum, of the cosmic ray spectrum above the GZK cutoff, and the cosmological measurement of the power spectrum governing the CMB and large scale structure. The first two approaches are sensitive to the mass eigenstate...
متن کاملBias in Absolute Magnitude Determination from Parallaxes
Relations are given for the correction of bias when mean absolute magnitudes are derived by the method of reduced parallaxes. The bias in the case of the derivation of the absolute magnitudes of individual objects is also considered.
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ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations of Crystallography
سال: 2012
ISSN: 0108-7673
DOI: 10.1107/s0108767312099928