Absolute Coronary Blood Flow Measured by Continuous Thermodilution in Patients With Ischemia and Nonobstructive Disease

Intracoronary continuous thermodilution is a novel technique to quantify absolute coronary flow (Q) and resistance (R) has potential advantages over current methods such as reserve (CFR) index of microvascular (IMR). However, no data are available in patients with ischemia nonobstructive artery disease (INOCA). This study aimed assess the relationship Q R established CFR/IMR INOCA patients, explore Q, predict self-reported angina. Consecutive (n = 84; 87% women; mean age 56 ± 8 years) underwent function testing, including acetylcholine (ACH) provocation adenosine (ADE) testing (CFR/IMR), (absolute R) saline-induced hyperemia. ACH was abnormal (ACH+) 87%, ADE (ADE+) 38%. The median 198 ml/min, 416 WU. higher ADE+ versus ADE− (495 WU vs. 375 WU; p 0.04) but did not differ between ACH+ ACH− (421 409 0.74). Low high were associated severe angina (odds ratio: 3.09; 95% confidence interval: 1.16 8.28; 0.03; odds 2.60; 0.99 6.81; 0.05), respectively. In this study, CFR/IMR, whereas both unrelated vasospasm. angina, although their exact predictive value should be determined larger studies.