Absence of beta Globin Synthesis and Excess of alpha Globin Synthesis in Homozygous beta-Thalassemia
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چکیده
منابع مشابه
Absence of Functional Messenger RNA Activity for Beta Globin Chain Synthesis in f3#{176}-Thalassemia
Functional human globin messenger RNA but failed to stimulate the synthesis of any was isolated from reticulocytes of two paf. -chains, even though nonthalassemic tients with homozygous /3#{176}-thalassemia, human globin mRNA preparations conthree patients with sickle cell fl#{176}-thalassistently stimulated two to four times as semia, and one patient doubly heteromuch fl or globin chain synthe...
متن کاملAbsence of Functional Messenger RNA Activity for Beta Globin Chain Synthesis in f3#{176}-Thalassemia
Functional human globin messenger RNA but failed to stimulate the synthesis of any was isolated from reticulocytes of two paf. -chains, even though nonthalassemic tients with homozygous /3#{176}-thalassemia, human globin mRNA preparations conthree patients with sickle cell fl#{176}-thalassistently stimulated two to four times as semia, and one patient doubly heteromuch fl or globin chain synthe...
متن کاملControlling alpha-globin: a review of alpha-globin expression and its impact on beta-thalassemia.
Synthesis of alpha-globin and alpha-globin subunits of hemoglobin occurs at high levels during erythrocyte differentiation in a tightly controlled and coordinated fashion. Expression of alpha-globin is a fascinatingly complex process which has been meticulously defined in several recent studies, from chromatin modifications to Pol II recruitment. Following this, alpha-globin transcripts are pro...
متن کاملGlobin chain synthesis in the marrow and reticulocytes of beta thalassemia, hemoglobin H disease, and beta delta thalassemia.
a, fi, and ‘i globin chain synthesis in bone marrow and peripheral blood reticulocytes were studied in two patients with thalassemia major, two with thalassemia intermedia, one with thaIassemia minor, one with Hb H disease, and one with homozygous f38-thalassemia. Nine nonthalassemic patients served as controls. In thalassemia major, a marked imbalance of ato fichain synthesis was found in the ...
متن کاملGlobin chain synthesis in the alpha thalassemia syndromes.
Whole blood samples of patients with various forms of alpha thalassemia including hemoglobin H disease, alpha thalassemia trait, and the "silent carrier" state were incubated with leucine-(14)C for definition of relative rates of production of alpha and beta chains in these disorders. The chains were separated by carboxymethyl cellulose chromatography in the presence of 8 M urea and dithiothrei...
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ژورنال
عنوان ژورنال: European Journal of Biochemistry
سال: 1967
ISSN: 0014-2956,1432-1033
DOI: 10.1111/j.1432-1033.1967.tb00046.x