ABNORMALITIES OF IN VITRO LYMPHOCYTE RESPONSES DURING RUBELLA VIRUS INFECTIONS
نویسندگان
چکیده
منابع مشابه
Abnormalities of in Vitro Lymphocyte Responses during Rubella Virus Infections
In vitro rubella virus infections of lymphocytes from normal adult humans impaired their responsiveness to phytohemagglutinin (PHA) stimulations; a situation which seemed analogous to the PHA unresponsiveness of peripheral lymphocytes from babies with the congenital rubella syndrome. Such in vitro viral infection of normal cells also decreased the synthesis of normal nucleic acids and structura...
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Lymphocyte and macrophage responses after vaccinia virus infections.
Using a semimicromethod with washed whole blood, in vitro lymphocyte responses of rabbits to intradermal infection with vaccinia virus was studied. Peritoneal exudate macrophages were infected with vaccinia in vitro to determine the time of appearance of activated macrophages. After primary infection, an increase in spontaneous incorporation of thymidine by blood cultures was found as early as ...
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Serum samples from patients with various forms of rubella virus infection were tested for antibodies to each of three viral structural proteins by radioimmunoprecipitation and sodium dodecyl sulfate-polyacrylamide gel electrophoresis. In most sera antibody to E1 protein was the predominant species. Sera from patients with congenital rubella syndrome, however, contained significantly more E2 ant...
متن کاملLymphocyte function and virus infections.
Lymphocytes in the blood and central lymphoid tissues participate in a variety of host defence mechanisms against virus infections. These include cell-mediated reactions against infected cells and particularly those involving cytotoxic T lymphocytes, co-operation in the induction of antibody responses, and the production of immune interferon. During the early stages of many virus infections the...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1968
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.128.1.47