Abnormal Mitosis in Tumours
نویسندگان
چکیده
منابع مشابه
Linking abnormal mitosis to the acquisition of DNA damage
Cellular defects that impair the fidelity of mitosis promote chromosome missegregation and aneuploidy. Increasing evidence reveals that errors in mitosis can also promote the direct and indirect acquisition of DNA damage and chromosome breaks. Consequently, deregulated cell division can devastate the integrity of the normal genome and unleash a variety of oncogenic stimuli that may promote tran...
متن کاملLinking abnormal mitosis to the acquisition of DNA damage Neil
Correspondence to Neil J. Ganem: [email protected] Introduction Progression from a nontransformed normal cell to a malignant cancer cell requires multiple genetic changes that hyperactivate oncogenes while restraining tumor suppressors (Hanahan and Weinberg, 2011). This occurs via two distinct, but not mutually exclusive, mechanisms: the acquisition of genetic mutations, and gene copy...
متن کاملCell death associated with abnormal mitosis observed by confocal imaging in live cancer cells.
Phenanthrene derivatives acting as potent PARP1 inhibitors prevented the bi-focal clustering of supernumerary centrosomes in multi-centrosomal human cancer cells in mitosis. The phenanthridine PJ-34 was the most potent molecule. Declustering of extra-centrosomes causes mitotic failure and cell death in multi-centrosomal cells. Most solid human cancers have high occurrence of extra-centrosomes. ...
متن کاملAbnormal anaphase resolution (aar): a locus required for progression through mitosis in Drosophila.
We describe a new mitotic locus of Drosophila melanogaster required for the progression through mitosis in the syncytial embryo and in late larval development. The locus aar (abnormal anaphase resolution) maps to the cytological interval 85E7-F16 and was identified by two alleles. The aar1 allele causes pupal lethality. Larval neuroblasts show an elevated mitotic index with high chromosome cond...
متن کاملThe ABNORMAL GAMETOPHYTES (AGM) gene product of Arabidopsis demonstrates a role in mitosis during gamete development.
Screening a T-DNA mutagenized population of Arabidopsis thaliana for reduced seed set and segregation distortion led to the isolation of the ABNORMAL GAMETOPHYTES (AGM) mutant. Homozygous plants were never recovered, but heterozygous plants showed mitotic defects during gametogenesis resulting in approximately 50% abortion of both the male and female gametes. Isolation of the genomic sequence f...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1947
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1947.5