Abnormal Mitochondrial DNA Molecules in Megamitochondria from Cuprizone-Treated Rats
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چکیده
منابع مشابه
Abnormal cardiac norepinephrine storage in isoproterenol-treated rats.
Repeated administration of large doses of isoproterenol to rats produced myocardial enlargement and a fall in blood pressure. A defect in storage of norepinephrine (NE) was manifested by a decrease in endogenous NE, unimpaired uptake of H-NE, and an accelerated rate of loss of accumulated H-NE. This accelerated loss of H-NE was characterized by a more rapid disappearance of H-NE from the granul...
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The mitochondrial DNA (mtDNA) in rodent-human hybrid somatic cells was studied in strains that contain nucleotide sequences from both parental mtDNAs. A test for linkage of rodent to human mtDNA was devised on the basis of the density and sequence differences between these DNAs. When a mixture of rodent and human mtDNAs was banded in a CsCl gradient and each fraction hybridized with a mixture o...
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Abuse of the powerfully addictive psychostimulant, methamphetamine, occurs worldwide. Recent studies have suggested that methamphetamine-induced dopaminergic neurotoxicity is related to oxidative stress. In response to nerve activation, the mitochondrial respiratory chain is rapidly activated. The enhancement of mitochondrial respiratory chain activation may induce oxidative stress in the brain...
متن کاملMitochondrial Dna from Protozoa1
is known from the extensive genetic studies made in yeast (EPHRUSSI 1958) I;nd Neurospora (WAGNER and MITCHELL 1955) that certain defects associated with mitochondrial proteins are inherited under the control of a cytoplasmic element. However, the chemical nature and the specific location of such an element in the cytoplasm have not yet been elucidated. In recent years, evidence has been accumu...
متن کاملCuprizone-induced demyelination in Wistar rats; electrophysiological and histological assessment.
OBJECTIVES Multiple Sclerosis (MS) is a disease that affects the Central Nervous System by destructing myelin shield and also can affects the peripheral nervous system. Demyelination is acquired characteristics disease and appears with the degeneration of myelin which protects the axons. Cuprizone (CPZ) model is a toxic demyelination model. The purpose of this study was to develop an MS model b...
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ژورنال
عنوان ژورنال: European Journal of Biochemistry
سال: 1974
ISSN: 0014-2956,1432-1033
DOI: 10.1111/j.1432-1033.1974.tb03695.x