Aberrant expression of cytokeratin 7 as a histological marker of progression in primary biliary cirrhosis
نویسندگان
چکیده
منابع مشابه
Serological and histological diagnosis of primary biliary cirrhosis.
A simple immunofluorescence test for antibody to a mitochondrial antigen present in many tissues is a reliable method of distinguishing most cases of primary biliary cirrhosis from jaundice due to extrahepatic biliary tract obstruction. Of 30 cases diagnosed as primary biliary cirrhosis, 26 had antimitochondrial antibody whereas none of 77 cases with jaundice due to extrahepatic bile duct obstr...
متن کاملImmunological and histological studies in primary biliary cirrhosis.
Thirty-one patients with primary biliary cirrhosis in whom adequate histological liver material was available were studied by immunological and histological methods. There was no statistically significant correlation between individual histological features and the level of serum mitochondrial antibodies. A relationship between the duration of symptoms and histological stage of the disease supp...
متن کاملPalmoplantar keratoderma as a presenting sign of primary biliary cirrhosis
P rimary biliary cirrhosis (PBC) is an autoimmune disease of the liver characterized by the presence of highly specific antimitochondrial antibodies with resulting immune-mediated injury of small intrahepatic bile ducts. Palmoplantar keratodermas (PPKs) are characterized by hyperkeratosis of the skin on the palms and soles. Multiple cases have been reported associating PPK with autoimmune thyro...
متن کاملHighlights of primary biliary cirrhosis
Primary biliary cirrhosis (PBC) is an autoimmune chronic cholestatic liver disease, histopathologically charac terized by portal inflammation and immunemediated destruction of the intrahepatic bile ducts within the portal tracts and epithelioid granulomas around damaged bile ducts. The loss of bile ducts leads to decreased bile secretion and the retention of toxic substances within the liver,...
متن کاملPathogenesis of primary biliary cirrhosis.
Autoimmune phenomena have been recognized in primary biliary cirrhosis (PBC) for more than 50 years and the specificity of the characteristic responses directed at highly conserved mitochondrial antigens determined in detail over the past 20. Effecter autoreactive immune responses are characterized and potential mechanisms of breakdown of tolerance to self proposed. Elements of the clinical pat...
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ژورنال
عنوان ژورنال: Liver
سال: 2001
ISSN: 0106-9543
DOI: 10.1034/j.1600-0676.2001.210108.x