AB1453 TRADITIONAL AND NON-TRADITIONAL CARDIOVASCULAR RISK FACTORS IN THE DEVELOPMENT OF EARLY ATHEROSCLEROSIS IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS AND RHEUMATOID ARTHRITIS

Background It is known that patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are characterized a variability of traditional non-traditional cardiovascular risk factors for the early development arthrosclerosis. The results numerous studies, examining significance these atherosclerosis in autoimmune rheumatic disease (ARD), contradictory. Additionally prevalence was compared between ARD healthy persons. There few data about comparison patient SLE, RA ischemic heart (IHD). Objectives aim our study to determine frequency occurrence SLE IHD assess their role atherosclerosis. Methods included 85 female (SLE (n=40), mean age 33,5 (27,5; 44,5) years old, duration 8,0 (5,0; 14,5) years, activity SLEDAI-2K 7,0 (4,0; 11,5) points (n=45), 43,0 (33,0; 52,0) 9,0 13,0) (DAS28=5,37 (4,69;5,89) points. Fifty four women same formed first control group (CG1), 22 (mean 50,0 (48,0; 51,0) old) made second (CG2). presence (age, arterial hypertension (AH), smoking, obesity, dyslipidemia, low physical activity, family history (CVD)) (menopause, hyperhomocysteinemia (HHC)) assessed. confirmed help common carotid artery sonography according standard procedures. Results found only AH HHC were more CG1 (AH: 65% vs. 0% (р<0,0001), HHC: 45% 9% respectively 27% 36% (р=0,001), patients). Age, CVD, menopause similar both groups CG1. revealed 14 younger (р<0,0001) than IHD. They had less often CVD (18% 41%, р=0,044), but 2 times (45% 22%, р=0,031) CG2. Patients 8 (р=0,007). Moreover AH, CG2 (27% 73% (р=0,0003), 40% 68% (р=0,030), 71% 95% (р=0,025), 11% 41% (р=0,005), respectively). detected 1,5 IHD, without statistically difference (36% p=0,288). Other subclinical observed 54% ARD. Comparative analysis investigated those has shown highest (54% p=0,014), what could be as result inflammation this patients. Conclusion Thus, we high (as factor) RA. More half may associated References [1]K. Tselios et al. J. Rheumatol. 2016; 43 (1): 54–65. [2]M. F. Piepoli Eur. Heart 37 2315–81. Disclosure Interests None declared