AB1073 HIGH INCIDENCE OF VIRUSES INFECTION IN CONNECTIVE TISSUE DISEASES PATIENTS

Background Connective tissue diseases (CTDs) are a group of with variety clinical manifestations. The main drug was glucocorticoids and immunosuppressive drugs, but the results not satisfactory side effects obvious, increased incidence infection, especially opportunistic infections. Infections becomes important causes morbidity mortality in CTD patients. Objectives To evaluate infection patients who were clinically considered for co-infection by combination metagenomic next-generation sequencing (mNGS) conventional diagnostic testing methods. Methods We analyzed 126 connective (CTD)patients suspected infections admitted to Second Hospital Shanxi Medical University. All diagnosed according relevant criteria, including 34 systemic lupus erythematosus (SLE), 24 dermatomyositis polymyositis (DM/PM), 19 rheumatoid arthritis (RA), 10 undifferentiated disease(UCTD),16 Sjogren syndrome (SS), 5 mixed disease (MCTD), ANCA associated systemtc vasculitis (AAV), adult onset Stillystemtc isease disease(tic 34nfections (TA), 1 sclerosis (SSC), 1retroperitoneal fibrosis (RPF). enrolled tested methods(CDT) mNGS. Results Among co-infection, 31 negative mNGS, pathogens detected 99 them. In our results, mNGS CDT both positive detection 28 individuals.Of individuals, 2 cases perfect matches,12 partly matched, 14 totally mismatched. A total 23 CDT. 70 only.There only only. addition, showed that 131 virus-positive(54%), 78 prokaryotes-positive (37%) inculding bacteria, mycoplasma eukaryotes-positive (9%). Of course, someones have among these patinets some patients, two or more pathogens. no viruses 38 virus 20 bacteria 4 bacteria,fungi 9 case bacteria,viruses,fungi bacteria,viruses fungi infection. According most common identified, followed prokaryotes eukaryotes. It is noteworthy Human gammaherpesvirus 4(EBV), betaherpesvirus 5(CMV) alphaherpesvirus virus-positive. frequently Acinetobacter baumannii, Mycobacterium tuberculosis complex, Staphylococcus aureus, Prevotella melaninogenica,Staphylococcus homini Helicobacter pylori. major Pneumocystis jirovecii Candida albicans individuals. Conclusion As complementary approach methods, could help improving identification patients.The viral high close attention should be paid it works. Figure 1. A. Comparison test between B. classification without methods(CDT). 2. Distribution Type distribution identified Species B.viruses, C.Prokayote, D. Eucayon Disclosure Interests None declared