AB1019 ANALYSIS OF DEMOGRAPHIC AND CLINICAL CHARACTERISTICS OF ENTEROPATHIC SPONDYLOARTHRITIS IN A TERTIARY CARE HOSPITAL

Background Enteropathic spondyloarthritis (eSpA), is a type of inflammatory joint disease that related to bowel diseases (IBD). Both (SpA) and IBD share clinical, genetic immunological features. Arthritis can occur before, during or after IBD. The treatment this based on the use NSAIDS corticoids as well csDMARDs bDMARDs. Objectives To describe demographic, clinical serological characteristics, onset pattern, radiological involvement, smoking habit, activity comorbidities such cardiovascular risk factors (CVRF) in patients with eSpA. analize most commonly used drugs these therapeutic response. Methods We performed descriptive observational study eSpA diagnosed Hospital León between 1980 2022. variables analysed were sex, date SpA, time two diagnoses, pattern SpA IBD, HLAB27, toxic habits, family history, arthralgias, uveítis, psoriasis, dactylitis, involvement (sacroilitis, syndesmophytes) treatments received. was assessed by BASDAI Index. Results patient´s features are shown Table 1. included 56 patients, half men women. 57,1% cases debut Crohn’s Disease (CD) represented 41,1% had peripheral (16,1% oligoarticular arthritis 25% polyarticular arthritis); 32,1% presented an axial 26,8% mixed pattern. Peripheral form. elapsed < 5 years 50% sample analyzed. HLAB27 positive 28,6% 35,7% showed > 4. found associated uveitis psoriasis 14,3% 16,1% cases. CVRF, prevalent dyslipemia (39,3%). 53,6% (sacroilitis 48.2%, syndesmophytes 21.4%). Radiological significantly greater smoker (p=0.003), probably due higher activity. 78.6% treated cDMARDs methotrexate (51.8%), followed azathioprine, 5-ASA, leflunomide. 73.2% received bDMARDs anti-TNF (73.2%), IL12-23 inhibitors, JAK inhibitors anti-integrin. frequent cause discontinuation side effects (16.1%), especially digestive intolerance; while secondary failure (19.6%) Demographic, features, eSPA patients. Conclusion In our study, enteropathic first intestinal symptoms. patterns Chron’s disease, we HLA B27+ around third sample. Smoking form sacroiliitis syndesmophytes. Multidisciplinary work gastroenterology rheumatology essential for diagnosis spondyloarthritis. These results consistent literature. Reference [1]Picchianti-Diamanti A, Lorenzetti R, Chimenti MS, et al. spondyloarthritis: from large nationwide database analysis. Autoimmun Rev. 2020 Feb;19(2):102457. Acknowledgements: NIL. Disclosure Interests None Declared.