AB0948 Osteoporotic screening and prevalence of severe osteoporotic fractures in a population of psoriatic arthritis initiating a biologic treatment

Background Osteoporosis is a common complication of Rheumatic diseases. The association between osteoporosis and rheumatoid arthritis clearly demonstrated while this still debated as well for the screening by Dual-Energy X-Ray Absorptiometry (DEXA) or to demonstrate an increased risk fracture on radiography in population Psoriatic Arthritis (PsA). prevalence fragility fractures reported medical reports ranged 12% 40% PsA patients. Only few studies evaluated vertebral (VF) spine radiographs. To our knowledge no study has contribution radiographic CT assessment records. Objectives determine patient’s characteristics screened DEXA initiating biologic treatment (bDMARD) estimate severe osteoporotic after imaging modalities scoring (X-ray CT-scan). Methods Patients with psoriasis should satisfy CASPAR ASAS criteria have been during their follow up bDMARD. Osteoporotic was defined BMD testing (DEXA). Vertebral were scored according Genant’s method X-ray sagittal CT-scan images. Clinical demographic data presence previous records collected. Results On 417 patients bDMARDs 2008-2019, 89 (21.3%) assessed DEXA. Increased age, female sex, menopause, fracture, disease duration, inflammatory bowel disease, current corticosteroid uses significantly associated screening. DEXA, 7 (7.9%) classified osteoporotic. 6.7% 23.6% radiographies TAP-CT In univariate analysis age (p=0.013), scanographic bone attenuation coefficient (p=0.005) Lumbar T-score (p=0.039). Conclusion Less than quarter bDMARD osteoporosis. are inferior 10%. After systematic evaluation, increases at 23.6%. References [1]Chandran S, Aldei A, Johnson SR, Cheung AM, Salonen D, Gladman DD. Prevalence factors low mineral density psoriatic arthritis: A review. Seminars Rheumatism. oct 2016 [2]Riesco M, Manzano F, Font P, García Nolla JM. densitometry fractures. Rheumatology. déc 2013 [3]Pedreira PG, Pinheiro MM, Szejnfeld VL. Bone body composition postmenopausal women arthritis. Res Ther. févr 2011 [4]Del Puente Esposito Costa L, Benigno C, Del Foglia et al. Fragility Fractures Arthritis. Journal Rheumatology Supplement. 1 nov 2015 [5]van der Weijden MAC, van Horst-Bruinsma IE, Denderen JC, Dijkmans BAC, Heymans MW, Lems WF. High frequency early spondylarthropathies. Osteoporos Int. juin 2012 [6]Pickhardt PJ, Pooler BD, Lauder T, del Rio Bruce RJ, Binkley N. Opportunistic Screening Using Abdominal Computed Tomography Scans Obtained Other Indications. Ann Intern Med. 16 avr [7]Kwok TSH, Sutton Yang Ye J, Pereira Chandran V, Care & Research. 2020 [8]Gulati AM cross-sectional outpatient clinic population. RMD Open. 2018 Disclosure Interests None declared