AB0854 CLINICAL CHARACTERISTICS OF PATIENTS WITH AMINOACYL-tRNA SYNTHETASES COMPARED WITH OTHER MYOSITIS ANTIBODIES IN A COHORT OF INFLAMMATORY MYOSITIS

Background The Idiopathic Inflammatory Myositis (IIM) are heterogeneous with different clinical profiles associated various myositis autoantibodies. Among the specific antibodies (MSA), against aminoacyl-tRNA synthetases(ARS) is related to clinically unique IIM subsets, Antisynthetase syndrome(ASS). Objectives aim of this study was identify prevalence and features patients ARS autoantibodies compared other in a single center cohort Korea. Methods Adult diagnosed positive for were recruited from January 2020 December 2022. Retrospective analysis performed based on data including features, laboratory data, high-resolution CT (HRCT) findings, pulmonary function manifestations. Results 82 patients, 25 57 had antibodies. most common antibody anti-EJ (n=10) followed by anti-PL-7 (n=8). MSA than included anti-SRP (n=6), anti-TIF1γ (n=11) anti-MDA-5(n=19). Anti-Ro52 detected 48 79.2% which accompanied manifestations respiratory symptoms, more commonly experienced (84% vs. 47.4%, p=0.002). Meanwhile, muscle weakness (32.0% 61.4%) dysphagia (8.0% 33.3%) less frequently exhibited those In regard group showed higher inflammatory markers group, mean (SD) erythrocyte sedimentation rate (ESR) 53.6 (34.6) 33.8 (24.3), respectively. anti-nuclear (ANA) cytoplasmic pattern group. Interstitial lung disease (ILD) also (88.0% 59.6%) non-specific interstitial pneumonia (NSIP) frequent ILD. However, there no significant differences baseline between two groups. Conclusion Patients symptoms while Moreover, ANA along References [1]DA SILVA, Lila Morena Bueno, et al. Demographic, clinical, prognostic, treatment antisynthetase syndrome: An international, two-center study. Archives Rheumatology, 2022, 37.3: 424-434. [2]GUPTA, Latika, Myositis-specific myositis-associated large Indian myositis. In: Seminars Arthritis Rheumatism. WB Saunders, 2021. p. 113-120. Table 1. Baseline characteristics (n=82) Ab(+) (n=25) Other (n=57) P Clinical feature, n (%) DOE 21 (84.0) 27 (47.4) 0.002 Weakness 8 (32.0) 35 (61.4) 0.014 Dysphagia 2 (8.0) 19 (33.3) 0.016 Fever 7 (28.0) (14.0) 0.132 Mechanic’s hand 11 (44.0) 17 (29.8) 0.213 Raynaud phenomenon 16 (28.1) 0.719 13 (22.8) 0.614 Laboratory findings ANA, 9 (36.0) (13.0) Ro52 22 (88.0) 26 (45.6) <0.001 ESR 53.56 ± 34.59 33.78 24.17 CRP 1.90± 2.19 0.76 1.62 0.028 PFT FVC 72.0 16.3 73.3 18.9 0.772 FEV1 75.5 14.1 81.5 21.0 0.152 DLCO 62.6 21.9 62.8 23.0 0.969 ILD, n(%) 34 (59.6) 0.011 NSIP (70.8) (44.9) 0.037 Acknowledgements: NIL. Disclosure Interests None Declared.