AB0757 TAKAYASU DISEASE: ABOUT 109 CASES

Background TAKAYASU disease is an inflammatory vasculitis of the means and large caliber, which affects th aorta its main branches, leads to formation arterial stenosis, thromboses aneurysms. Touching preferably young women, it may be responsible for complications severe visceral events that life-threatening. Methods We conducted a 38-year, single-centric retrospective study (1984 2022) in patients followed at department internal medicine vascular surgery Ibn Sina Hospital Rabat. Statistical data were analyzed using SPSS 20. 0 software KHI- DEUX analytical test. Results collected 109 files. The sex ratio (F/M) was 7. 3 (96 women/ 13 men). 11. 92% male. mean age 34. 8 ±11. 9 (12 – 62 years). Patients who had juvenile takayasu diagnosed before 20 years 11 (10%) late-diagnosed over 50 14 (12. 88%). HTA present 44 (40. 7%) diagnosis, (10. 1) taking oral contraceptives. Inflammatory syndrome associated 72 (66. 1%) with no statistically significant difference P=0. 6. Vascular symptomatology 103 (95. 4%) cases o murmur 1%), pulse suppression (62. 4%), intermittent claudication (49. 5%) ischemia 1%). Extravascular symptoms 47. 6% dominated by arthralgia (18. 3%). Only one patient asymptomatic discovered chance during ultrasound examination thyroid nodule. Cardiac involvement occurred 36 (33%) consisted mainly valvulopathy (20. 2%) cardiomyopathy (17. 4%). Central neurological 17 patients. (15. 6%) complicated HAI Renal impairment 35 (32. 11%). Ophthalmologic 26 (23. 9%) represented retinal optic nerve involvement. In addition, 10 24 pregnancies, 4 preeclampsia, we recorded abortions half our full term pregnancies. type injury series stenosis found 73 (67%) cases. Occlusion recovered 21 (19. 3%) Thrombosis aneurysms 19 Type I 42 (38. patients, V 39 (35. 8%). IIa 7 (6. IIb (3. 7%), III 2 (1. 8%), IV Most 104 received corticosteroids 77 (70. immunosuppressive therapy including on mycophenolate mofetil. anti-TNF (adalimumab) 1 Tocilizumab. At surgical level; (8. angioplasty; A further 6 underwent cardiac (5 aortic valve replacement closed-heart commissurotomy) 15 (13. 8%) surgery. outcome favourable majority Late relapses > months reported 25 There only death from global heart failure. several associations such as disease, disease. None returned P ranging 0. 1. Conclusion results are consistent literature confirm predominance women stenosing nature this vasculitis. Early diagnosis management significantly improves progression profile REFERENCES: NIL. Acknowledgements: Disclosure Interests Declared.