AB0332 IS MINOR SALIVARY GLAND HISTOLOGY A GOOD BIOMARKER SCORE TO PREDICT THE EXTRAGLANDULAR INVOLVEMENT IN PATIENTS WITH PRIMARY SJOGREN’S SYNDROME?

Background: The minor salivary gland biopsy (MSGB) is considered the “ gold standard ” for diagnosis of primary Sjögren’s syndrome (pSS). histological hallmark focal lymphocytic infiltration with presence 50 or more lymphocytes per 4 mm 2 (focus score ≥ 1). Several studies have documented association between focus (FS) and extraglandular involvement, suggesting that FS could be used as a index disease severity prognostic tool. Objectives: To investigate clinical, haematological serological findings in cohort patients pSS. Methods: We performed retrospective analysis pSS who fulfilled ACR/EULAR 2016 classification criteria were submitted to (MSGB). Demographic data, duration, involvement histopathologic data collected analyzed. histologic changes was graded according Chisholm Mason scoring system determined. Fisher’s exact test/Chi-square test Mann-Whitney U compare without positive (FS <1 versus Futhermore, quantitative value groups each manifestations authors test. P-value < 0.05 statistically significant. Results: A total 59 included. Regarding pattern, 40 had 1, while 19 <1. Although described having pathologists failed report absolute 11 (27,5%) patients. Germinal center-like structures found 1 (1,7%) patient. demographic clinical features are presented table 1. Anti-SSA strongly associated (p <0,001). No significant difference two groups. Table (* exact/Chi-square test; † T-test; ‡ test). (n=19 ) (n=48 p-value Gender (female), n (%) 17 (89,5) 34 (85,0) 0,639 * Current age (years) (mean ± SD) 60,11+-13,39 54,78 (+-13,48) 0.16 Disease duration (median, P25-P75) 3 (2-7) (3-5) 0,507 Extraglandular Arthralgias/Arthritis, 6 (31,7) 22 (55,0) 0,092 Myositis, 0 (0) (2,5) - Pulmonary (15,8) 5 (12,5) 0,704 PNS CNS Cutaneous (5,3) 0,544 Lymphoma, (5,6) Haematological characteristics Leukocytopenia, Hypergammaglobulinaemia, 10 (52,6) 16 (40,0) 0,361 RF positivity, (26,3) (25,6) ANA 18 (94,7) 0,411* (100) 21 (52,5) 0,001 Anti-SSB 7 (36,8) 12 (32,5) 0,742 ESSDAI (0-8) (0-7,25) 0,816 When comparing manifestation, articular higher than (p=0.037). other found. Conclusion: manifestations, we didn’t find those <1, which corroborates importance anti-SSA negative biopsy. involvement. However, this study has limitations such small sample low incidence manifestations. In conclusion, needed clarify associations literature. Disclosure Interests: None declared