AB0021 FEATURES OF IMMUNOLOGICAL MANIFESTATIONS OF СOMMON VARIABLE IMMUNODEFICIENCY COMBINED WITH RHEUMATOID ARTHRITIS

Background The prevalence rate of сommon variable immunodeficiency (CVID), the most common symptomatic form primary disease (PID), is growing every year. In Republican Register PID in Chuvash Republic (Russia) there are 32 patients with CVID, 5 (15.6%) whom have CVID combined an autoimmune - rheumatoid arthritis (RA). immunological studies occupy a large place diagnosis and diseases. Objectives aim study was to search for criteria differentiation RA from RA. Methods object were 2 groups patients. Group 1 consisted 20 patients; group combination Patients who had results conducted before appointment immunoglobulin replacement therapy, selected this study. control practically healthy people. Results significant changes revealed concentration serum immunoglobulins studied patients, particular, sharp decrease IgG levels (1.9±0.3 g/l vs. 15.2±2.3 1, p<0.001), IgA (0.1±0.02 3.1±0.7 IgM (0.2±0.03 1.7±0.2 p<0.001). Immunoglobulin both lower (p<0.001) compared group. groups, number regulatory cells – Treg (CD4+CD25+FoxP3) reduced: 2.5±0.03%; 2.3± 0.02%, while it 4.2± 0.5%, p<0.001. result our confirms that development associated responsible ensuring peripheral tolerance preventing Conclusion immunopathological sign content blood. differential between RA, necessary rely on determination blood serum. Disclosure Interests None declared