AAV Vectors Containing rDNA Homology Display Increased Chromosomal Integration and Transgene Persistence
نویسندگان
چکیده
منابع مشابه
AAV vectors containing rDNA homology display increased chromosomal integration and transgene persistence.
Although recombinant adeno-associated viral (rAAV) vectors are promising tools for gene therapy of genetic disorders, they remain mostly episomal and hence are lost during cell replication. For this reason, rAAV vectors capable of chromosomal integration would be desirable. Ribosomal DNA (rDNA) repeat sequences are overrepresented during random integration of rAAV. We therefore sought to enhanc...
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ژورنال
عنوان ژورنال: Molecular Therapy
سال: 2012
ISSN: 1525-0016
DOI: 10.1038/mt.2012.157