A46, a benzothiophene-derived compound, suppresses Jak2-mediated pathologic cell growth
نویسندگان
چکیده
منابع مشابه
Z3, a novel Jak2 tyrosine kinase small-molecule inhibitor that suppresses Jak2-mediated pathologic cell growth.
Jak2 tyrosine kinase is essential for animal development and hyperkinetic Jak2 function has been linked to a host of human diseases. Control of this pathway using Jak2-specific inhibitors would therefore potentially serve as a useful research tool and/or therapeutic agent. Here, we used a high-throughput program called DOCK to predict the ability of 20,000 small molecules to interact with a str...
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ژورنال
عنوان ژورنال: Experimental Hematology
سال: 2012
ISSN: 0301-472X
DOI: 10.1016/j.exphem.2011.10.003