A20 Is a Negative Regulator of IFN Regulatory Factor 3 Signaling

Regulatory Factor 3 Signaling A20 Is a Negative Regulator of Ifn

A20 is a negative regulator of IFN regulatory factor 3 signaling.

IFN regulatory factor 3 (IRF-3) is a critical transcription factor that regulates an establishment of innate immune status following detection of viral pathogens. Recent studies have revealed that two IkappaB kinase (IKK)-like kinases, NF-kappaB-activating kinase/Traf family member-associated NF-kappaB activator-binding kinase 1 and IKK-i/IKKepsilon, are responsible for activation of IRF-3, but...

IFN regulatory factor 10 is a negative regulator of the IFN responses in fish.

IFN regulatory factor (IRF) 10 belongs to the IRF family and exists exclusively in birds and fish. Most IRFs have been identified as critical regulators in the IFN responses in both fish and mammals; however, the role of IRF10 is unclear. In this study, we identified IRF10 in zebrafish (Danio rerio) and found that it serves as a negative regulator to balance the innate antiviral immune response...

of July 29 , 2017 . This information is current as Regulatory Factor 3 Signaling A 20 Is a Negative Regulator of IFN

Negative regulation of IFN- signaling by IFN regulatory factor 2 for homeostatic development of dendritic cells

The development and cooperation of distinct subsets of antigenpresenting cells, particularly dendritic cells (DCs), may be critical for maintaining homeostatic immune responses. Recently, much attention has been focused on IFN, the cytokines induced en masse by virus infection or the activation of Toll-like receptors, in the context of DC activation. Here, we show that mice deficient in IFN reg...