A2-purinoceptor-mediated relaxation in the guinea-pig coronary vasculature: a role for nitric oxide
نویسندگان
چکیده
منابع مشابه
Nitric oxide modulates coronary autoregulation in the guinea pig.
A guinea pig heart Langendorff preparation was used in the present study to test the hypothesis that the coronary endothelium modulates coronary autoregulation through the production of nitric oxide (NO). Pacing at 250 beats per minute and venting the left ventricle to ensure that the hearts did no external work were performed in an attempt to reduce the metabolic stimulus to coronary vasomotio...
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It is a well-established fact that adenosine and its receptor subtypes (A 1 and A ) are involved in changes of contractility, heart rate and coronary blood flow (CBF) under different circumstances. This study was conducted to evaluate the role of nitric oxide and prostaglandins in development of these changes. For this purpose, Nitro-L-Arginine methyl ester (L-NAME), and indomethacin as inhibit...
متن کاملChronic 17beta-estradiol replacement increases nitric oxide-mediated vasodilation of guinea pig coronary microcirculation.
BACKGROUND Estrogen is cardioprotective of the coronary circulation by mechanisms incompletely understood. This study determined the effect of chronic 17beta-estradiol replacement on dilator responses to acetylcholine and sodium nitroprusside of the isolated coronary microcirculation. METHODS AND RESULTS Adult female guinea pigs were ovariectomized, and a 21-day-release pellet containing 0.0,...
متن کاملChronic 17b-Estradiol Replacement Increases Nitric Oxide–Mediated Vasodilation of Guinea Pig Coronary Microcirculation
Background—Estrogen is cardioprotective of the coronary circulation by mechanisms incompletely understood. This study determined the effect of chronic 17b-estradiol replacement on dilator responses to acetylcholine and sodium nitroprusside of the isolated coronary microcirculation. Methods and Results—Adult female guinea pigs were ovariectomized, and a 21-day-release pellet containing 0.0, 0.1,...
متن کاملthe role of nitric oxide and prostaglandins in the effect of adenosine on contractility, heart rate and coronary blood flow in guinea pig isolated heart
it is a well-established fact that adenosine and its receptor subtypes (a 1 and a ) are involved in changes of contractility, heart rate and coronary blood flow (cbf) under different circumstances. this study was conducted to evaluate the role of nitric oxide and prostaglandins in development of these changes. for this purpose, nitro-l-arginine methyl ester (l-name), and indomethacin as inhibit...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1993
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1993.tb13586.x