A unique set of SH3–SH3 interactions controls IB1 homodimerization
نویسندگان
چکیده
منابع مشابه
The Structure of the RAGE:S100A6 Complex Reveals a Unique Mode of Homodimerization for S100 Proteins.
S100 proteins are calcium-dependent regulators of homeostatic processes. Upon cellular response to stress, and notably during tumorigenesis, they relocalize to the extracellular environment where they induce pro-inflammatory signals by activating the receptor for advanced glycation end products (RAGE), thereby facilitating tumor growth and metastasis. Despite its importance in sustaining inflam...
متن کاملThe scaffold protein IB1/JIP-1 controls the activation of JNK in rat stressed urothelium.
The c-Jun N-terminal kinase (JNK) is critical for cell survival, differentiation, apoptosis and tumorigenesis. This signalling pathway requires the presence of the scaffold protein Islet-Brain1/c-Jun N-terminal kinase interacting protein-1 (IB1/JIP-1). Immunolabeling and in situ hybridisation of bladder sections showed that IB1/JIP-1 is expressed in urothelial cells. The functional role of IB1/...
متن کاملInfluenza: A Unique Disease
Dear Editor-in-Chief, Influenza, commonly known as the flu, is an infectious disease caused by an influenza virus (1). Symptoms can be mild to severe (2). The most common symptoms include: high fever, runny nose, sore throat, muscle pains, headache, coughing, sneezing, and feeling tired (1). Three of the four types of influenza viruses affect people, Type A, Type B, and Type C (3, 4). Type D ha...
متن کاملDiabetes in the elderly. A unique set of management challenges.
The overall goals in regard to management of diabetes in the elderly are twofold. First, blood glucose control should be kept as near normal as possible (certainly always less than 200 mg/dl) without inordinately increasing risks related to therapy; this will decrease the risk of acute complications and hopefully of long-term ones as well. Second, overall functional status should be maintained ...
متن کاملUnique S100 target protein interactions.
Three-dimensional structures of S100B, S100A1, S100A6 and S100A11 have shown that calcium binding to these proteins results in a conformational change allowing them to interact with many biological targets. The structures of some S100 proteins in the presence of peptide targets from Ndr kinase, p53, CapZ, annexins A1 and A2 and the Siah-1 Interacting Protein indicate there are at least three mo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2006
ISSN: 0261-4189,1460-2075
DOI: 10.1038/sj.emboj.7600982