A two-step mechanism for the inactivation of microtubule organizing center function at the centrosome
نویسندگان
چکیده
منابع مشابه
SPD-2/CEP192 and CDK Are Limiting for Microtubule-Organizing Center Function at the Centrosome
The centrosome acts as the microtubule-organizing center (MTOC) during mitosis in animal cells. Microtubules are nucleated and anchored by γ-tubulin ring complexes (γ-TuRCs) embedded within the centrosome's pericentriolar material (PCM). The PCM is required for the localization of γ-TuRCs, and both are steadily recruited to the centrosome, culminating in a peak in MTOC function in metaphase. In...
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ژورنال
عنوان ژورنال: eLife
سال: 2019
ISSN: 2050-084X
DOI: 10.7554/elife.47867