A two-stage design with two co-primary endpoints
نویسندگان
چکیده
منابع مشابه
A Two-Stage Design with Two Correlated Co-Primary Endpoints
Simon two-stage design is often applied to phase II singlearm oncology trials where a binary outcome is of interest [2]. The trial design allows us to explore potential efficacy and safety signals quickly while limiting the number of patients exposed to an inefficacious new treatment. In the well-known Simon two stage design, hypotheses are typically set up as H : P P = vs. : A A H P P = , wher...
متن کاملA Two-Stage Hybrid Flowshop Scheduling Problem with Serial Batching
In this paper the problem of serial batch scheduling in a two-stage hybrid flow shop environment with minimizing Makesapn is studied. In serial batching it is assumed that jobs in a batch are processed serially, and their completion time is defined to be equal to the finishing time of the last job in the batch. The analysis and implementation of the prohibited transference of jobs among the mac...
متن کاملOptimal two-stage designs for single-arm phase II oncology trials with two binary endpoints.
OBJECTIVES In phase II clinical trials in oncology, the potential efficacy of a new treatment regimen is assessed in terms of anticancer activity. The standard approach consists of a single-arm two-stage design where a single binary endpoint is compared to a specified target value. However, a new drug would still be considered promising if it showed a lower tumor response rate than the target l...
متن کاملTwo-stage DEA with Fuzzy Data
Data envelopment analysis is a nonparametric technique checking efficiency of DMUs using math programming. In conventional DEA, it has been assumed that the status of each measure is clearly known as either input or output. Kao and Hwang (2008) developed a data envelopment analysis (DEA) approach for measuring efficiency of decision processes which can be divided into two stages. The first stag...
متن کاملTwo-stage Sample Design with Small Clusters
In two-stage surveys, the sample size of clusters and units within clusters can be chosen to minimise the variance of an estimator, for fixed cost. This paper considers sample designs where the number of units to be selected from each cluster is a function of the cluster size. If there are only a small number of units in each cluster, as in household surveys, then the optimisation should be ove...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Contemporary Clinical Trials Communications
سال: 2015
ISSN: 2451-8654
DOI: 10.1016/j.conctc.2015.08.002