A “traffic control” role for TGFβ3: orchestrating dermal and epidermal cell motility during wound healing
نویسندگان
چکیده
منابع مشابه
A “traffic control” role for TGFβ3: orchestrating dermal and epidermal cell motility during wound healing
Cell migration is a rate-limiting event in skin wound healing. In unwounded skin, cells are nourished by plasma. When skin is wounded, resident cells encounter serum for the first time. As the wound heals, the cells experience a transition of serum back to plasma. In this study, we report that human serum selectively promotes epidermal cell migration and halts dermal cell migration. In contrast...
متن کاملThe anti-motility signaling mechanism of TGFβ3 that controls cell traffic during skin wound healing
When skin is wounded, migration of epidermal keratinocytes at the wound edge initiates within hours, whereas migration of dermal fibroblasts toward the wounded area remains undetectable until several days later. This "cell type traffic" regulation ensures proper healing of the wound, as disruptions of the regulation could either cause delay of wound healing or result in hypertrophic scars. TGFβ...
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This paper contains a review of our recent work on the mathematical modeling of cell interaction with extracellular matrix components during the process of dermal wound healing. The models are of partial differential equation type and allow us to investigate in detail how various mechanochemical effects may be responsible for certain wound healing disorders such as fibrocontractive and fibropro...
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Epidermal repair during wound healing is under investigation at both the light and electron microscopic levels. Suction-induced subepidermal blisters have been employed to produce two complementary model wound healing systems. These two model systems are: (a) intact subepidermal blisters, and (b) opened subepidermal blisters (the blister roof was removed immediately after induction, leaving an ...
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In normal undamaged skin the dermis supports the epidermis mechanically and supplies it nourishment. Because the epidermis has no blood supply of its own its need for oxygen, glucose, amino-acid molecules and other metabolites are met from the dermis. These molecules diffuse through the basement membrane, a combined epidermal-dermal structure and travel in the fluid between the epidermal cells ...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2006
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem2034oia11