A Toxicological Study on Seed Extracts of Asparagus Racemosus Linn (Ethanolic and Water) in Experimental Animals

The study investigated the in-vivo oral acute toxicity and in-vitro cytotoxicity (Neutral red assay (NRU) by Aqueous Ethanol extract of Asparagus racemosus Linn seed. In this study, water was found to be more toxic zebrafish. medium lethal concentration (LD50) values ethanol were 1070.8 mg/L 1822.4 respectively for 96 hours exposure. correlation coefficient 0.972 0.9829 linear regression curves between death percentage. also 50% 100 % mortality observed with 968mg/L 2129.6 extract, whereas only 28.57% 57.14% in same range. lower concentrations, such as 90.90 mg/L, 200mg/L 440 having no mortality, considered safe vitro (NRU assay) on SH-SY5Y cell line, trend where line. results indicate that 43% caused Ethanolic at 500 μg/ml concentration. Hence, IC50 value 562.1 μg/ml, approximately 52% inhibition recorded μg/mL aqueous extract. 114.7 Both studies showed less toxic, hence effective compared