A tool compound targeting the core binding factor Runt domain to disrupt binding to CBFβ in leukemic cells
نویسندگان
چکیده
منابع مشابه
Cooperative binding of DNA and CBFβ to the Runt domain of the CBFα studied via MD simulations
The Runt domain (RD) is the DNA-binding region of the Runx genes. A related protein, known as core binding factor beta (CBFbeta) also binds to the RD to enhance RD-DNA interaction by 6- to 10-fold. Here, we report results from molecular dynamics (MD) simulations of RD alone, as a dimer in complexes with DNA and CBFbeta and in a ternary complex with DNA and CBFbeta. Consistent with the experimen...
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ژورنال
عنوان ژورنال: Leukemia & Lymphoma
سال: 2017
ISSN: 1042-8194,1029-2403
DOI: 10.1080/10428194.2017.1410882