A TNF Antagonist Synthesized from TNF/TNF Receptor Contact Site Inhibits Osteoclastogenesis
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چکیده
منابع مشابه
Tumor necrosis factor (TNF)-soluble high-affinity receptor complex as a TNF antagonist.
A novel high-affinity inhibitor of tumor necrosis factor (TNF) is described, which is created by the fusion of the extracellular domains of TNF-binding protein 1 (TBP-1) to both the alpha and beta chains of an inactive version of the heterodimeric protein hormone, human chorionic gonadotropin. The resulting molecule, termed TNF-soluble high-affinity receptor complex (SHARC), self-assembles into...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 2000
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)47652-x