A therapeutic human IgG4 monoclonal antibody that depletes target cells in humans
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چکیده
منابع مشابه
Therapeutic Discovery A Monoclonal Antibody against Human Notch1 Ligand– Binding Domain Depletes Subpopulation of Putative Breast Cancer Stem–like Cells
Overexpression ofNotch receptors and ligands has been associatedwith various cancers anddevelopmental disorders,makingNotch a potential therapeutic target.Here,we report characterization ofNotch1monoclonal antibodies (mAb) with therapeutic potential. The mAbs generated against epidermal growth factor (EGF) repeats 11 to 15 inhibited binding of Jagged1 andDelta-like4 and consequently, signaling ...
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ژورنال
عنوان ژورنال: Clinical and Experimental Immunology
سال: 1996
ISSN: 0009-9104,1365-2249
DOI: 10.1046/j.1365-2249.1996.d01-876.x