A Systematic Approach to HIV-1 Vaccine Immunogen Selection
نویسندگان
چکیده
منابع مشابه
Generation and Characterization of a Defective HIV-1 Virus as an Immunogen for a Therapeutic Vaccine
BACKGROUND The generation of new immunogens able to elicit strong specific immune responses remains a major challenge in the attempts to obtain a prophylactic or therapeutic vaccine against HIV/AIDS. We designed and constructed a defective recombinant virus based on the HIV-1 genome generating infective but non-replicative virions able to elicit broad and strong cellular immune responses in HIV...
متن کاملDiversity considerations in HIV-1 vaccine selection.
Globally, human immunodeficiency virus-type 1 (HIV-1) is extraordinarily variable, and this diversity poses a major obstacle to AIDS vaccine development. Currently, candidate vaccines are derived from isolates, with the hope that they will be sufficiently cross-reactive to protect against circulating viruses. This may be overly optimistic, however, given that HIV-1 envelope proteins can differ ...
متن کاملA global approach to HIV-1 vaccine development
A global human immunodeficiency virus-1 (HIV-1) vaccine will have to elicit immune responses capable of providing protection against a tremendous diversity of HIV-1 variants. In this review, we first describe the current state of the HIV-1 vaccine field, outlining the immune responses that are desired in a global HIV-1 vaccine. In particular, we emphasize the likely importance of Env-specific n...
متن کاملStabilization of Gp120 Outer Domain for Hiv-1-1 Vaccine Immunogen Design
The sole envelope glycoprotein spike on the surface of Human Immunodeficiency Virus (HIV-1) is composed of two subunits: gp120 and gp41. The gp120 consists of three domains: the inner domain, outer domain and bridging sheet, to which the viral primary receptor CD4 binds and induces a conformational change in gp120 to expose the co-receptor binding site. Previous studies have found that the oute...
متن کاملBrian Gaschen , Diversity Considerations in HIV - 1 Vaccine Selection
http://www.sciencemag.org/cgi/content/full/296/5577/2354 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/296/5577/2354/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http:/...
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ژورنال
عنوان ژورنال: AIDS Research and Human Retroviruses
سال: 2020
ISSN: 0889-2229,1931-8405
DOI: 10.1089/aid.2019.0239