A Syrian Golden Hamster Model Recapitulating Ebola Hemorrhagic Fever

A Syrian golden hamster model recapitulating ebola hemorrhagic fever.

Ebola hemorrhagic fever (EHF) is a severe viral infection for which no effective treatment or vaccine is currently available. While the nonhuman primate (NHP) model is used for final evaluation of experimental vaccines and therapeutic efficacy, rodent models have been widely used in ebolavirus research because of their convenience. However, the validity of rodent models has been questioned give...

Ebola Hemorrhagic Fever and Marburg Hemorrhagic Fever

media coverage when outbreaks occur. The causative organisms are found in tropical Africa and the Philippines. They belong to the Filoviridae family. Clinical presentations of the viral infections they cause share many common characteristics. At least 6 Marburg virus outbreaks and 21 Ebola virus outbreaks have been documented to date (Table 1). More outbreaks have probably occurred in remote ar...

ebola hemorrhagic fever

context ebola hemorrhagic fever (ehf) is amongst severe and fatal viral hemorrhagic fevers. in february 2014, a strain of the ebola virus appeared in guinea and then in liberia, sierra leone, and mali. the aim of this study was to review the literature on ehf and discuss its routes of transmission and prevention. evidence acquisition we searched medical databases (pubmed, scopus) from july 1970...

Ebola Hemorrhagic Fever

Intussusception in the Syrian golden hamster.

Of a series of ninety-six young male Syrian Golden hamsters, 13% developed lethargy, anorexia, diarrhoea and colocolic intussusception when their diet was changed from a basal laboratory-grade rodent chow to a nutritionally complete semi-purified diet. Histologically, the colon of the hamsters with intussusception had markedly reduced mucus production. Plasma levels of gastric inhibitory polype...