A subset of infectious proviruses persist and expand following activation ex vivo
نویسندگان
چکیده
منابع مشابه
HIV-1 Virion Production from Single Inducible Proviruses following T-Cell Activation Ex Vivo.
Quantifying induced virion production from single proviruses is important for assessing the effects of HIV-1 latency reversal agents. Limiting dilution ex vivo cultures of resting CD4(+) T cells from 14 HIV-positive volunteers revealed that virion production after T-cell activation from individual proviruses varies by 10,000-fold to 100,000-fold. High-producing proviruses were associated with i...
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The fate of HIV-infected cells after reversal of proviral latency is not well characterized. Simonetti, et al. recently showed that CD4+ T-cells containing intact proviruses can clonally expand in vivo and produce low-level infectious viremia. We hypothesized that reversal of HIV latency by activation of CD4+ T-cells can lead to the expansion of a subset of virus-producing cells rather than the...
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ژورنال
عنوان ژورنال: Journal of Virus Eradication
سال: 2015
ISSN: 2055-6640
DOI: 10.1016/s2055-6640(20)31318-2