A study on effect of vitamin d supplementation in vitamin D deficient females with polycystic ovarian syndrome

نویسندگان

چکیده

Background: Polycystic ovarian syndrome is one of the most common metabolic and endocrine disorders among women, whereas vitamin D a steroid with hormone like activity also considered as missing link between insulin resistance PCOS due to its underlying mechanism action in reducing thereby altering pathogenesis behind symptoms.Methods: A prospective cohort comparative observational study was carried out from July 2019 December 2020 96 deficient females (polycystic ovarian-syndrome). All were randomly recruited under group B equal proportion 1:1, where given metformin (500 mg twice daily) only plus 60000 IU weekly for 24 weeks. Baseline clinical, hormonal, metabolic, sonographic parameters compared before after treatment.Results: Significant improvement seen various both groups, oligomenorrhoea improved 41.67% individuals. FG score mean 10.28±2.02 8.44±2.23 p<0.0001. Acne groups equally 22.92%. ovary pattern 14.58% individuals Serum total testosterone 16.71% 22.92% B. HOMA-IR reduced effectively statistically significant p=0.017 p=0.001 B.Conclusions: Remarkable noteworthy reduction HOMA-IR, BP triglyceride values seen. Hence, supplementation highly effective improving preventing future consequences well.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Pnm-29: Effects of Vitamin D Supplementation in Reproductive Function of Women with Polycystic Ovary Syndrome

Background Vitamin D deficiency is common in women with PCOS. Vitamin D is thought to influence the development of PCOS through gene transcription, and hormonal modulation influences insulin metabolism and fertility regulation. Therefore, the aim of this review article is to study the effects of vitamin D supplementation in reproductive function of PCOS women. MaterialsAndMethods This review ar...

متن کامل

Effect of vitamin D supplementation on insulin kinetics and cardiovascular risk factors in polycystic ovarian syndrome: a pilot study

To assess the effect of vitamin D supplementation on parameters of insulin sensitivity/resistance (IS/IR) and insulin secretion in subjects with polycystic ovarian syndrome (PCOS). A prospective double-blind randomized control trial was conducted to assess the effect of vitamin D on insulin kinetics in women with PCOS. The trial was conducted in a tertiary care research hospital. A total of 36 ...

متن کامل

Effect of Vitamin D Supplementation on Pancreatic Β -Cell Function in Patients with Type 1 Diabetes Mellitus and Vitamin D Deficiency: A Clinical Trial Study

Background Considering the increasing prevalence of type 1 diabetes mellitus (T1DM) as an autoimmune disease in recent years and the positive effects of vitamin D (VD) on this disease, especially the preventive effect of VD on progressive reduction of pancreatic β-cells, we aimed to investigate the effect of VD on pancreatic β-cell function in T1DM patients. Materials and Methods From Sep 2016 ...

متن کامل

Treatment of vitamin D deficiency with high-dose vitamin D supplementation and its effect on hematological indices in pregnancy: A secondary analysis of a randomized clinical trial

Introduction: There are few studies regarding the treatment of vitamin D deficiency with a high dose of vitamin D and the comparison of serum vitamin D levels and hematological indices (Hemoglobin, Hematocrit, Platelet and Ferritin) in the first and second trimesters of pregnancy. The aim of this study was to evaluate the effect of vitamin D supplementation on these hematological indices in pre...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: International journal of reproduction, contraception, obstetrics and gynecology

سال: 2022

ISSN: ['2320-1770', '2320-1789']

DOI: https://doi.org/10.18203/2320-1770.ijrcog20222300