A study on bone marrow derived stem cells and its application on ACL graft regeneration in partial ACL tears

نویسندگان

چکیده

Background: Partial tears of the anterior cruciate ligament (ACL) are frequent, and there is still considerable controversy surrounding their diagnosis, natural history treatment. Aim: To examine patient-reported outcomes, physical examination magnetic resonance imaging (MRI) findings partial ACL treated with an intraarticular injection BMAC to evaluate both subjective objective clinical results as compare outcomes Pre Procedure, at 3 weeks months following procedure, well functional recovery time.Methods: From April July 2023, consecutive patients from a single institution nonoperatively were prospectively evaluated. defined positive Lachman test clear endpoint, negative pivot-shift MRI taken classified graded on basis VAN MEER Radiological Classification. Patients one specific therapy protocol. Prospective analyzed data included Lysholm International Knee Documentation Committee scores months. Baseline follow-up reviewed. Failure was those instability that required reconstruction Results: A total 30 where included, all mean Their Mean Age 40. 20 (60%) them men 40 % females, Overall failure rate (n = 3). One patient (5.0%) unable RTS due instability. The other 95.0% in each group able return previous sports level. Regarding stability, 6 month 1, 19 presented decrease side-to-side difference, 10 remained same 1 had 2 mm more, over all, time Significant differences observed regarding sport Following Procedure. revealed improvement signal half patients. However, we did not find significant relationship between outcomes. Conclusion: Overall, returned mo. addition shows promise treatment grade 2, possibly without retraction. Further investigation using controlled study design warranted.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Bone regeneration with rabbit bone marrow-derived mesenchymal stem cells and bone graft materials.

PURPOSE This study compared the bone regeneration response of different bone graft materials inside canals within anodized titanium implants in cortical and cancellous bone. MATERIALS AND METHODS Upper and lower transverse canals were created in anodic oxidized-surface titanium implants to serve as sites for cortical and cancellous bone regeneration, respectively. The canals were filled with ...

متن کامل

ACL Revision in Synthetic ACL graft failure

The development of synthetic grafts as an alternative to biological grafts for reconstruction of the anterior cruciate ligament dates from 1980. The interest is awakened due to the potential advantages of: The absence of morbidity associated with donor site, and early return to sport . However, this surgical technique has had multiple complications associated with graft: mechanical failures (sy...

متن کامل

CFU-GM Like Colonies Derived from Embryonic Stem Cells Cultured on the Bone Marrow Stromal Cells

The aim of this study was to isolate mouse embryonic stem cells from late blastocyst stage embryos and to use them as a model system for the study of hematopoietic induction outside the embryo by coculturing of embryonic stem cells with bone marrow stromal cells. Blastocyst stage embryos from pregnant NMRI mice were obtained and cultured for 1-2 days in DMEM medium. The inner cell masses formed...

متن کامل

The Effect of Bone Marrow Graft on Bone Healing: A Radiological and Biomechanical Study

Background: There are multiple methods for acceleration of bone healing. Bone marrow has been shown to contain osteoprogenitor cells. Objective: To determine the effect of percutaneous bone marrow injection on bone healing. Methods: 15 mature, 2-kg-weighing white New Zealand rabbits from both sexes were randomized into 3 groups: Group I: Only osteotomy of right radius was performed and a 5 mm b...

متن کامل

Calcitriol modulates the effects of bone marrow-derived mesenchymal stem cells on macrophage functions

Objective(s):Some evidence showed that calcitriol has an important role in regulating growth and differentiation of mesenchymal stem cells (MSCs). However, the interaction between mesenchymal stem cells and macrophage is not clear yet.  The current study was done to investigate the in vitro effects of calcitriol on the interactions between bone marrow-derived MSCs and rat macrophages. Material...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: International Journal of Orthopaedics Sciences

سال: 2023

ISSN: ['2395-1958']

DOI: https://doi.org/10.22271/ortho.2023.v9.i3d.3433