A study of the proteomic expression in patients with complicated parapneumonic pleural effusion

Introduction The present study aimed to investigate the differences in proteomic expression between uncomplicated parapneumonic pleural effusion (UPPE) and complicated (CPPE). Material methods There were 10 patients with UPPE CPPE. These combined due complication of further divided into group A B. An LC-MS analysis was conducted extraction high-abundance proteins, proteins 1.5-fold or higher difference multiples identified as differential proteins. Then, gene ontology (GO) KEGG analyses on groups. Results Compared group, there 38 upregulated 29 downregulated CPPE group. GO revealed that had enhanced expressions monosaccharide biosynthesis, glucose catabolism, fructose-6-phosphate glycolysis, glucose-6-phosphate NADH regeneration well reduced fibrinogen complexes, protein polymerization, coagulation. Moreover, showed amino acid synthesis, HIF-1 signalling pathway, glycolysis/glyco-isogenesis decreased platelet activation complement activation. Conclusions In CPPE, are concerning metabolism, regeneration, pathways together blood coagulation, activation,